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Genetics Faculty

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Peter Scacheri
Ph.D. Training Faculty
Department of Genetics
School of Medicine
Case Western Reserve University
Biomedical Research Building 628
2109 Adelbert Road
Cleveland, Ohio 44106-4955
Tel: (216) 368-3458
Fax: (216) 368-3432

About Peter Scacheri

Peter Scacheri graduated with a BS in Biology from Gettysburg College and earned his Ph.D. in Biochemistry and Molecular Genetics from the University of Pittsburgh. His graduate work was focused on the molecular mechanisms underlying dominantly inherited forms of muscular dystrophy. His postdoctoral fellowship was in the lab of Francis Collins at the National Human Genome Research Institute at the National Institutes of Health. There he combined mouse genetics and genomics to study a type of cancer that affects the endocrine organs. Peter won several awards during his postdoctoral fellowship, including the NHGRI Intramural Research Award for outstanding scientific achievement. In 2006, Peter joined the Case Western Reserve University School of Medicine as an Assistant Professor in Department of Genetics and Genome Sciences, and he is a member of the Case Comprehensive Cancer Center. Peter's research program is focused on understanding the role of epigenetics and the histone code in human health and disease. He has been awarded several NIH grants and he has published more than 40 papers on a broad variety of topics related to genetics, genomics, and bioinformatics. In 2013, Peter was promoted to the level of Associate Professor with tenure.

Selected Publications

Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits.
Corradin O, Saiakhova A, Akhtar-Zaidi B, Myeroff L, Willis J, Cowper-Sal Lari R, Lupien M, Markowitz S, Scacheri PC
Genome Res (2014);24(1):1-13
See PubMed abstract

Genomic Characterization of the Mouse Ribosomal DNA Locus.
Zentner GE, Balow SA, Scacheri PC
G3 (Bethesda) (2013);:
See PubMed abstract

Knockdown of fbxl10/kdm2bb rescues chd7 morphant phenotype in a zebrafish model of CHARGE syndrome.
Balow SA, Pierce LX, Zentner GE, Conrad PA, Davis S, Sabaawy HE, McDermott BM, Scacheri PC
Dev Biol (2013);:
See PubMed abstract

Twist1 mediates repression of chondrogenesis by β-catenin to promote cranial bone progenitor specification.
Goodnough LH, Chang AT, Treloar C, Yang J, Scacheri PC, Atit RP
Development (2012);139(23):4428-38
See PubMed abstract

Histone demethylase UTX and chromatin remodeler BRM bind directly to CBP and modulate acetylation of histone H3 lysine 27.
Tie F, Banerjee R, Conrad PA, Scacheri PC, Harte PJ
Mol Cell Biol (2012);32(12):2323-34
See PubMed abstract

Epigenomic enhancer profiling defines a signature of colon cancer.
Akhtar-Zaidi B, Cowper-Sal-lari R, Corradin O, Saiakhova A, Bartels CF, Balasubramanian D, Myeroff L, Lutterbaugh J, Jarrar A, Kalady MF, Willis J, Moore JH, Tesar PJ, Laframboise T, Markowitz S, Lupien M, Scacheri PC
Science (2012);336(6082):736-9
See PubMed abstract

Otitis media in a new mouse model for CHARGE syndrome with a deletion in the Chd7 gene.
Tian C, Yu H, Yang B, Han F, Zheng Y, Bartels CF, Schelling D, Arnold JE, Scacheri PC, Zheng QY
PLoS One (2012);7(4):e34944
See PubMed abstract

H3K4me3 inversely correlates with DNA methylation at a large class of non-CpG-island-containing start sites.
Balasubramanian D, Akhtar-Zaidi B, Song L, Bartels CF, Veigl M, Beard L, Myeroff L, Guda K, Lutterbaugh J, Willis J, Crawford GE, Markowitz SD, Scacheri PC
Genome Med (2012);4(5):47
See PubMed abstract

Rapid and robust generation of functional oligodendrocyte progenitor cells from epiblast stem cells.
Najm FJ, Zaremba A, Caprariello AV, Nayak S, Freundt EC, Scacheri PC, Miller RH, Tesar PJ
Nat Methods (2011);8(11):957-62
See PubMed abstract

Epigenetic signatures distinguish multiple classes of enhancers with distinct cellular functions.
Zentner GE, Tesar PJ, Scacheri PC
Genome Res (2011);:
See PubMed abstract

Integrative genomic analysis of human ribosomal DNA
Gabriel E. Zentner, Alina Saiakhova, Pavel Manaenkov, Mark D. Adams, Peter C. Scacheri
Nucleic Acids Research (2011);doi: 10.1093

Mutations in the CHD7 Gene: The Experience of a Commercial Laboratory.
Bartels CF, Scacheri C, White L, Scacheri PC, Bale S
Genet Test Mol Biomarkers (2010);14(6):881-91
See PubMed abstract

Role of canonical Wnt signaling/{beta}-catenin via Dermo1 in cranial dermal cell development.
Tran TH, Jarrell A, Zentner GE, Welsh A, Brownell I, Scacheri PC, Atit R
Development (2010);:
See PubMed abstract

CHD7 functions in the nucleolus as a positive regulator of ribosomal RNA biogenesis.
Zentner GE, Hurd EA, Schnetz MP, Handoko L, Wang C, Wang Z, Wei CL, Tesar PJ, Hatzoglou M, Martin DM, Scacheri PC.
Human Molecular Genetics (2010);doi:10.1093

Molecular and phenotypic aspects of CHD7 mutation in CHARGE syndrome.
Zentner GE, Layman WS, Martin DM, Scacheri PC
Am J Med Genet A (2010);152A(3):674-686
See PubMed abstract

CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression.
Schnetz MP, Handoko L, Akhtar-Zaidi B, Bartels CF, Pereira CF, Fisher AG, Adams DJ, Flicek P, Crawford GE, Laframboise T, Tesar P, Wei CL, Scacheri PC
PLoS Genet (2010);6(7):e1001023
See PubMed abstract

Functional studies of menin through genetic manipulation of the Men1 homolog in mice.
Balasubramanian D, Scacheri PC
Adv Exp Med Biol (2009);668:105-15
See PubMed abstract

CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing.
Tie F, Banerjee R, Stratton CA, Prasad-Sinha J, Stepanik V, Zlobin A, Diaz MO, Scacheri PC, Harte PJ
Development (2009);136(18):3131-41
See PubMed abstract

ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways.
Tao M, Scacheri PC, Marinis JM, Harhaj EW, Matesic LE, Abbott DW
Curr Biol (2009);19(15):1255-63
See PubMed abstract

Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns.
Schnetz MP, Bartels CF, Shastri K, Balasubramanian D, Zentner GE, Balaji R, Zhang X, Song L, Wang Z, Laframboise T, Crawford GE, Scacheri PC
Genome Res (2009);:
See PubMed abstract

Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets.
Johnson DS, Li W, Gordon DB, Bhattacharjee A, Curry B, Ghosh J, Brizuela L, Carroll JS, Brown M, Flicek P, Koch CM, Dunham I, Bieda M, Xu X, Farnham PJ, Kapranov P, Nix DA, Gingeras TR, Zhang X, Holster H, Jiang N, Green RD, Song JS, McCuine SA, Anton E, Nguyen L, Trinklein ND, Ye Z, Ching K, Hawkins D, Ren B, Scacheri PC, Rozowsky J, Karpikov A, Euskirchen G, Weissman S, Gerstein M, Snyder M, Yang A, Moqtaderi Z, Hirsch H, Shulha HP, Fu Y, Weng Z, Struhl K, Myers RM, Lieb JD, Liu XS
Genome Res (2008);18(3):393-403
See PubMed abstract

Epitope tagging of endogenous proteins for genome-wide ChIP-chip studies.
Zhang X, Guo C, Chen Y, Shulha HP, Schnetz MP, LaFramboise T, Bartels CF, Markowitz S, Weng Z, Scacheri PC, Wang Z
Nat Methods (2008);5(2):163-5
See PubMed abstract

Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation.
Agarwal SK, Impey S, McWeeney S, Scacheri PC, Collins FS, Goodman RH, Spiegel AM, Marx SJ
Neoplasia (2007);9(2):101-7
See PubMed abstract

DNase-chip: A high resolution method to identify DNaseI hypersensitive sites using tiled microarrays,
Crawford GE, Davis S,Scacheri PC,Renaud G, Halawi MJ, Erdos MR, Green R, Meltzer PS, Wolfsberg TG, Collins FS.
Nature Methods (2006);3:503-9
See PubMed abstract

Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis.
Scacheri PC, Davis S, Odom DT, Crawford GE, Perkins S, Halawi MJ, Agarwal SK, Marx SJ, Spiegel AM, Meltzer PS, Collins FS.
PLoS Genet. (2006);2(4):e51
See PubMed abstract

Statistics for ChIP-chip and DNAse hypersensitivity experiments on NimbleGen arrays.
Scacheri PC, Crawford GE, Davis S.
Methods Enzym. (2006);411:270-82
See PubMed abstract

Menin molecular interactions: insights into normal functions and tumorigenesis.
Agarwal SK, Kennedy PA, Scacheri PC, Novotny EA, Hickman AB, Cerrato A, Rice TS, Moore JB, Rao S, Ji Y, Mateo C, Libutti SK, Oliver B, Chandrasekharappa SC, Burns AL, Collins FS, Spiegel AM, Marx SJ.
Horm Metab Res. (2005);37(6):369-74
See PubMed abstract

Homozygous loss of menin is well tolerated in liver, a tissue not affected in MEN1.
Scacheri PC, Crabtree JS, Kennedy AL, Swain GP, Ward JM, Marx SJ, Spiegel AM, Collins FS.
Mamm Genome. (2004);15(11):872-7
See PubMed abstract

Pancreatic insulinomas in multiple endocrine neoplasia, type I knockout mice can develop in the absence of chromosome instability or microsatellite instability.
Scacheri PC, Kennedy AL, Chin K, Miller MT, Hodgson JG, Gray JW, Marx SJ, Spiegel AM, Collins FS.
Cancer Res. (2004);64(19):7039-44
See PubMed abstract

Molecular pathology of the MEN1 gene.
Agarwal SK, Lee Burns A, Sukhodolets KE, Kennedy PA, Obungu VH, Hickman AB, Mullendore ME, Whitten I, Skarulis MC, Simonds WF, Mateo C, Crabtree JS, Scacheri PC, Ji Y, Novotny EA, Garrett-Beal L, Ward JM, Libutti SK, Richard Alexander H, Cerrato A, Parisi MJ, Santa Anna-A S, Oliver B, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ.
Ann N Y Acad Sci. (2004);1014:189-98
See PubMed abstract

Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells.
Scacheri PC, Rozenblatt-Rosen O, Caplen NJ, Wolfsberg TG, Umayam L, Lee JC, Hughes CM, Shanmugam KS, Bhattacharjee A, Meyerson M, Collins FS.
Proc Natl Acad Sci U S A. (2004);101(7):1892-7
See PubMed abstract

Of mice and MEN1: Insulinomas in a conditional mouse knockout.
Crabtree JS, Scacheri PC, Ward JM, McNally SR, Swain GP, Montagna C, Hager JH, Hanahan D, Edlund H, Magnuson MA, Garrett-Beal L, Burns AL, Ried T, Chandrasekharappa SC, Marx SJ, Spiegel AM, Collins FS.
Mol Cell Biol. (2003);23(17):6075-85
See PubMed abstract

Microarray analysis using amplified mRNA from laser capture microdissection of microscopic hepatocellular precancerous lesions and frozen hepatocellular carcinomas reveals unique and consistent gene e
Yim SH, Ward JM, Dragan Y, Yamada A, Scacheri PC, Kimura S, Gonzalez FJ.
Toxicol Pathol. (2003);31(3):295-303
See PubMed abstract

Novel mutations in collagen VI genes: expansion of the Bethlem myopathy phenotype.
Scacheri PC, Gillanders EM, Subramony SH, Vedanarayanan V, Crowe CA, Thakore N, Bingler M, Hoffman EP.
Neurology. (2002);58(4):593-602
See PubMed abstract

Bidirectional transcriptional activity of PGK-neomycin and unexpected embryonic lethality in heterozygote chimeric knockout mice.
Scacheri PC, Crabtree JS, Novotny EA, Garrett-Beal L, Chen A, Edgemon KA, Marx SJ, Spiegel AM, Chandrasekharappa SC, Collins FS.
Genesis. (2001);30(4):259-63
See PubMed abstract

A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors.
Crabtree JS, Scacheri PC, Ward JM, Garrett-Beal L, Emmert-Buck MR, Edgemon KA, Lorang D, Libutti SK, Chandrasekharappa SC, Marx SJ, Spiegel AM, Collins FS.
Proc Natl Acad Sci U S A. (2001);98(3):1118-23
See PubMed abstract

A novel ryanodine receptor gene mutation causing both cores and rods in congenital myopathy.
Scacheri PC, Hoffman EP, Fratkin JD, Semino-Mora C, Senchak A, Davis MR, Laing NG, Vedanarayanan V, Subramony SH.
Neurology. (2000);12;55(11):1689-96.
See PubMed abstract

Unique PABP2 mutations in "Cajuns" suggest multiple founders of oculopharyngeal muscular dystrophy in populations with French ancestry.
Scacheri PC, Garcia C, Hebert R, Hoffman EP.
Am J Med Genet. (1999);86(5):477-81
See PubMed abstract

nimO, an Aspergillus gene related to budding yeast Dbf4, is required for DNA synthesis and mitotic checkpoint control.
James SW, Bullock KA, Gygax SE, Kraynack BA, Matura RA, MacLeod JA, McNeal KK, Prasauckas KA, Scacheri PC, Shenefiel HL, Tobin HM, Wade SD.
J Cell Sci. (1999);112 ( Pt 9):1313-24.
See PubMed abstract

Asymptomatic dystrophinopathy.
Morrone A, Zammarchi E, Scacheri PC, Donati MA, Hoop RC, Servidei S, Galluzzi G, Hoffman EP.
Am J Med Genet. (1997);69(3):261-7.
See PubMed abstract

De novo der(X)t(X;10)(q26;q21) with features of distal trisomy 10q: case report of paternal origin identified by late replication with BrdU and the human androgen receptor assay (HAR).
Garcia-Heras J, Martin JA, Witchel SF, Scacheri PC.
J Med Genet (1997);34: 242-245

Genetic counseling of isolated carriers of Duchenne muscular dystrophy.
Hoffman EP, Pegoraro E, Scacheri PC, Burns RG, Taber JW, Weiss L, Spiro A, and Blattner P.
Am J Med Genet (1996);63: 573-580

The Aspergillus nidulans bimE (blocked-in-mitosis) gene encodes multiple cell cycle functions involved in mitotic checkpoint control and mitosis.
James SW, Mirabito PM, Scacheri PC, Morris NR.
J Cell Sci. (1995);108 ( Pt 11):3485-99
See PubMed abstract