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Genetics

Thomas LaFramboise, PhD

Tom LaFramboise earned his B.S. from the University of Michigan at Ann Arbor and his Ph.D. from the University of Illinois at Urbana-Champaign, both degrees in theoretical mathematics. In 2002, Tom decided to retrain in biostatistics, earning a Master's degree at the Harvard School of Public Health, which led to a postdoctoral position in cancer genomics in the laboratory of Matthew Meyerson at the Dana-Farber Cancer Institute and the Broad Institute of Harvard/MIT. He joined the Department of Genetics and Genome Sciences at the Case Western Reserve University School of Medicine in August 2006.

Laboratory Focus

Broadly, our laboratory is interested in developing and applying computational tools to identify molecular variants - both inherited and somatic - that contribute to cancer in humans. We are currently developing and applying methods to mine high-dimensional data sets, with the goal of generating hypotheses regarding gene function in tumor initiation, progression, and metastasis. We then test these hypotheses in the laboratory using human cancer cells.